Mechanisms of vascular disease : a textbook for vascular specialists /

Mechanisms of vascular disease : a textbook for vascular specialists /

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This extensively revised third edition provides a practically applicable guide to the pathophysiology, assessment and management of vascular disorders encountered in vascular surgical practice. It features detailed information on the latest developments in the pathophysiology of conditions including...

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Bibliographic Details
Other Authors: Fitridge, Robert
Format: Book
Language:English
Published: Cham, Switzerland : Springer, 2020
Edition:3rd edition
Subjects:
Blood > Diseases
Blood-vessels > Diseases
Vascular Diseases > physiopathology
Vascular Diseases > therapy
Blood-vessels > Surgery
Internal medicine
Electronic books
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Table of Contents:
  • Intro
  • Contents
  • Abbreviations
  • Chapter 1: Vascular Endothelium in Health and Disease
  • 1.1 Introduction
  • 1.2 Endothelium-Dependent Regulation of Vascular Tone
  • 1.2.1 Gaseous Mediators
  • 1.2.2 Endothelium-Dependent Hyperpolarisation
  • 1.2.3 Metabolites of Arachidonic Acid
  • 1.2.4 Endothelins
  • 1.3 Angiogenesis
  • 1.4 Haemostasis
  • 1.5 Inflammation
  • 1.6 Conclusions
  • References
  • Further Reading
  • Chapter 2: Pathophysiology of Atherosclerosis
  • 2.1 Introduction
  • 2.2 Normal Vessel Wall
  • 2.3 Stages of Atherosclerosis
  • 2.3.1 Intimal Xanthomas or Fatty Streaks
  • 2.3.2 Fibroatheroma
  • 2.3.3 Thin-Cap Fibroatheroma
  • 2.3.4 Plaque Rupture
  • 2.3.5 Fibrous Calcified Plaque
  • 2.3.6 Plaque Erosion
  • 2.4 Pathophysiology of Atherosclerosis and Atherothrombosis
  • 2.4.1 Endothelial Dysfunction
  • 2.4.2 Lipoprotein Entry and Modification
  • 2.4.3 Leukocyte Recruitment
  • 2.4.4 Foam Cell Formation
  • 2.4.5 Lymphocyte Responses
  • 2.4.6 Smooth Muscle Cell Migration and Fibrous Cap Formation
  • 2.4.7 Macrophage Apoptosis and Necrotic Core Formation
  • 2.4.8 Calcification
  • 2.4.9 Neovascularisation and Intraplaque Haemorrhage
  • 2.4.10 Fibrous Cap Degradation and Plaque Rupture
  • 2.4.11 Plaque Erosion
  • 2.5 The Role of Inflammation in Atherosclerosis
  • 2.6 Risk Factors
  • 2.6.1 Genetic Risk Factors
  • 2.6.2 Traditional Risk Factors
  • 2.7 Conclusion
  • References
  • Further Reading
  • Chapter 3: Mechanisms of the Vulnerable Atherosclerotic Plaque and Imaging
  • 3.1 Introduction
  • 3.2 Plaque Rupture
  • 3.2.1 Thin Cap Fibroatheromas
  • 3.2.2 Plaque Size and Positive Luminal Remodeling
  • 3.2.3 Lipid-Rich Necrotic Core
  • 3.2.4 Neovascularisation and Plaque Haemorrhage
  • 3.2.5 Calcification
  • 3.3 Plaque Erosion
  • 3.4 Calcified Nodules
  • 3.5 Effect of Diabetes on Plaque Morphology
  • 3.6 Carotid Imaging
  • 3.6.1 Carotid Ultrasound
  • 3.6.2 Carotid Computed Tomography
  • 3.6.3 Carotid Magnetic Resonance Imaging
  • 3.7 Molecular Imaging
  • 3.7.1 Imaging Inflammation: Fluorodeoxyglucose (18F-FDG)
  • 3.7.2 Imaging Microcalcification: Sodium Fluoride (18F-NaF)
  • 3.8 Intravascular Imaging
  • 3.8.1 Intravascular Ultrasound (IVUS)
  • 3.8.2 Optical Coherence Tomography (OCT)
  • 3.8.3 Intravascular Molecular Imaging
  • 3.9 Conclusion: Vulnerable Plaques and Vulnerable Patients
  • References
  • Further Reading
  • Chapter 4: Current and Emerging Therapies for Atherosclerosis
  • 4.1 Introduction
  • 4.2 Risk Stratification
  • 4.3 Lifestyle Measures
  • 4.4 Anti-platelet and Anti-thrombotic Therapies
  • 4.5 Blood Pressure Therapies
  • 4.6 LDL Cholesterol Lowering Therapies
  • 4.7 Additional Lipid Modifying Therapies
  • 4.8 Glucose Lowering Therapies
  • 4.9 Anti-Inflammatory Therapies
  • 4.10 Obesity Targeted Therapies
  • 4.11 Cardiac Rehabilitation
  • 4.12 Conclusion
  • References
  • Further Reading
  • Chapter 5: Pathophysiology of Angiogenesis and Its Role in Vascular Disease
  • 5.1 Introduction

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