Chronic obstructive pulmonary disease : cellular and molecular mechanisms /
"Emphasizing the urgent need to clearly understand the underlying cellular and molecular mechanisms involved in COPD, this reference provides an up-to-date perspective on the inflammatory cells, mediators, and molecular pathology of COPD."--BOOK JACKET
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| Format: | Book |
| Language: | English |
| Published: |
Boca Raton, FL :
Taylor & Francis,
[2005], ©2005
Boca Raton, FL : c2005 Boca Raton, FL : [2005] |
| Series: | Lung biology in health and disease ;
v. 198 Lung biology in health and disease ; v. 198 |
| Subjects: | |
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Table of Contents:
- Why more research into molecular and cellular mechanisms of COPD is needed
- Inflammation in lung parenchyma
- Small airways disease in COPD
- Asthma vs. COPD: cellular and molecular differences
- Airway mucus secretion
- Macrophages
- Neutrophils
- Epithelial cells
- T-Lymphocytes
- Inflammatory mediators
- Oxidative stress
- Proteinases in COPD
- Antiproteases
- Corticosteroid resistance in COPD
- Molecular genetics
- Mechanisms of systemic effects
- Mechanisms of exacerbations of chronic obstructive pulmonary disease
- Mechanisms of pulmonary vascular changes
- Therapeutic implications and future developments
- Introduction / Claude Lenfant
- 1 Why more research into molecular and cellular mechanisms of COPD is needed / Peter J. Barnes
- 2. Inflammation in lung parenchyma / Graziella Turato, Simonetta Baraldo, Elisabetta Balestro, Renzo Zuin and Marina Saetta
- 3. Small airways disease in COPD / James C. Hogg
- 4. Asthma vs. COPD : cellular and molecular differences / Leonardo M. Fabbri, Fabrizio Luppi, Micaela Romagnoli and Lorenzo Corbetta
- 5. Airway mucus secretion / Duncan F. Rogers
- 6. Macrophages / Peter J. Barnes
- 7. Neutrophils / Elizabeth Sapey and Robert A. Stockley
- 8. Epithelial cells / John R. Spurzem and Stephen I. Rennard
- 9. T-lymphocytes / Manuel G. Cosio
- 10. Inflammatory mediators / Peter J. Barnes
- 11. Oxidative stress / Irfan Rahman
- 12. Proteinases in COPD / Steven D. Shapiro
- 13. Antiproteases / Noel G. McElvaney and Clifford Taggart
- 14. Corticosteroid resistance in COPD / Kazuhiro Ito, Ian M. Adcock and Peter J. Barnes
- 15. Molecular genetics / Xiaozhu Zhang and Andrew J. Sandford
- 16. Mechanisms of systemic effects / Alvar G. N. Agusti, Jaume Sauleda, Aina Noguera and Xavier Busquets
- 17. Mechanisms of exacerbations of chronic obstructive pulmonary disease / Jadwiga A. Wedzicha
- 18. Mechanisms of pulmonary vascular changes / Joan A. Barbera, Victor I. Peinado and Robert Rodriguez-Roisin
- 19. Therapeutic implications and future developments / Peter J. Barnes.
- Introduction / Claude Lenfant
- 1 Why more research into molecular and cellular mechanisms of COPD is needed / Peter J. Barnes
- 2. Inflammation in lung parenchyma / Graziella Turato, Simonetta Baraldo, Elisabetta Balestro, Renzo Zuin and Marina Saetta
- 3. Small airways disease in COPD / James C. Hogg
- 4. Asthma vs. COPD : cellular and molecular differences / Leonardo M. Fabbri, Fabrizio Luppi, Micaela Romagnoli and Lorenzo Corbetta
- 5. Airway mucus secretion / Duncan F. Rogers
- 6. Macrophages / Peter J. Barnes
- 7. Neutrophils / Elizabeth Sapey and Robert A. Stockley
- 8. Epithelial cells / John R. Spurzem and Stephen I. Rennard
- 9. T-lymphocytes / Manuel G. Cosio
- 10. Inflammatory mediators / Peter J. Barnes
- 11. Oxidative stress / Irfan Rahman
- 12. Proteinases in COPD / Steven D. Shapiro
- 13. Antiproteases / Noel G. McElvaney and Clifford Taggart
- 14. Corticosteroid resistance in COPD / Kazuhiro Ito, Ian M. Adcock and Peter J. Barnes
- 15. Molecular genetics / Xiaozhu Zhang and Andrew J. Sandford
- 16. Mechanisms of systemic effects / Alvar G. N. Agusti, Jaume Sauleda, Aina Noguera and Xavier Busquets
- 17. Mechanisms of exacerbations of chronic obstructive pulmonary disease / Jadwiga A. Wedzicha
- 18. Mechanisms of pulmonary vascular changes / Joan A. Barbera, Victor I. Peinado and Robert Rodriguez-Roisin
- 19. Therapeutic implications and future developments / Peter J. Barnes.