RNa interference pathways in the African trypanosome, Trypanosoma brucei
I also characterized a role for a novel Dicer-like protein (Dcl2) in the T. brucei RNAi pathway. Dcl2 is a nuclear protein that can cleave a double-stranded RNA substrate in vitro. Much in the same way that Ago1 ablation induces RNAi-deficiency, knocking out Dcl2 leads to an upregulation of retrotra...
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| Format: | Thesis Electronic Book |
| Language: | English |
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2008
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Internet
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